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The Bubbling Kassina is a very distinctive looking frog, with its olive-green skin color, which can look almost gold. Populations from the Taita Hills of Kenya are covered with regular black spots, each of which has a white ring around it, while other populations have stripes on the dorsum.

The Bubbling Kassina occurs throughout almost all of sub-Saharan Africa. It is found in suitable habitats at low and high altitudes, from Senegal to Somalia and southward to South Africa, Swaziland, and Lesotho.

Amphibian defensive skin secretions are complex species-specific mixtures of biologically active molecules, including many uncharacterized peptides. Many of these peptides are post-translationally modified and amongst the modifications discovered so far on amphibian defense peptides, disulfide bonds are quite frequently encountered.